Biodegradable Polymer Microneedles for Controlled-release Drug Delivery

Biopharmaceuticals, which include proteins, DNA, vaccines and other biologically related molecules, make up one of the fastest growing segments of the overall pharmaceutical market. However, there are significant delivery limitations. Specifically, oral delivery is difficult due to Poor absorption and degradation that occurs in the GI tract and liver and more sensitive drugs including proteins must survive the harsh environment of gastro intestinal tract. Transdermal drug delivery is an attractive alternative that involves transport of drugs across skin from a patch. This present review focused to increase the skin permeability different methods like chemical enhancers, electric fields, ultra sound and thermal methods have been approached. However the application of these has been limited because of strong barrier function of the skin. The future of drug delivery is assured to be significantly influenced by micro fabrication technologies. These micro fabricated drug delivery devices can enable efficient drug delivery that was unattainable with conventional drug delivery techniques, resulting in the enhancement of the therapeutic activity of a drug.